After an official announcement, the makers announced that Shruti Hassan is onboard as the heroine in this film. Now, the makers announced the arrival of multi-talented Tamil actor Samudrakani into their team. Samudrakani is a national-award-winning actor known for his tremendous performances in films like 'Raguvaran B.tech', 'Visaranai', 'Vada Chennai' and many more. He became a regular face in Tamil cinema. He is also playing a negative role in Trivikram's 'Ala Vaikunthapuramlo'. #RT66 will be his second direct Telugu film.
This film is directed by Gopichand Malineni and produced by Tagore Madhu. Thaman who is in super form is composing music for this police story.